The Guide for Zebrafish Care and Use is a guide that requires PHS-funded and AAALAC-accredited facilities to use as the basis for setting up a zebrafish care and use program. The authors describe how zebrafish have been employed for studying hemostasis and thrombosis using modern genome editing techniques. Zebrafish embryo/larva has emerged as a potential tool to test the teratogenicity potential of these chemicals. Zebrafish respond to compounds as they do with other animals.
PHS-funded and AAALAC-accredited facilities are required to use the Guide as the basis for setting up a zebrafish care and use program. The guide recommends a stocking density of 5 fish per liter for adult zebrafish. Zebrafish facility managers can contribute to the progress of a semiannual facility inspection by maintaining fully accessible operating records and presenting a well.
In recent decades, zebrafish embryo/larva has emerged as a potential tool to test the teratogenicity potential of these chemicals. Zebrafish respond to compounds as they do with other animals. The Guide also provides information about genomic resources available from NCBI.
In summary, the Guide for Zebrafish Care and Use is a comprehensive guide that outlines the requirements for facilities to set up a zebrafish care and use program. It includes guidelines on fumonisin B 1 production by Fusarium species and their mycotoxigenic effect on larval zebrafish. Facility managers can contribute to the progress of a semiannual facility inspection by maintaining fully accessible operating records and presenting well-presented data.
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